Thursday, March 23, 2017
12:00pm – 1:00pm
CGSB, CCAM Conference Room, R1673, 400 Farmington Ave
CCAM Seminar Series Speaker: Travis Hinson, M.D., Assistant Professor, The Pat & Jim Cardiology Center, The Jackson Laboratory for Genomic Medicine Title: "Engineered cardiac tissues to study genetic forms of human heart failure" Short abstract: "Heart failure currently affects 5.8 million patients in the US and 23 million worldwide, and is expected to increase unless new therapies are developed. In this presentation, I will introduce two types of genetic forms of human heart failure called cardiomyopathies. Familial dilated and hypertrophic cardiomyopathies that affect 1/250 and 1/500 patients, respectively. By creating engineered tissues of these genetic disorders by applying a combination of CRISPR-based genome editing with human iPS-differentiated cardiomyocytes, I will discuss human tissue-level mechanisms of these disorders. Using deep functional analysis of tissue mechanics, cell signaling and expression changes, I will attempt to connect mechanical changes that alter signaling to structural abnormalities of the heart that are observed in human patients. Finally, I will show potential therapeutic candidates that were discovered from this approach."
Contact: Tiffany x6103
Center for Cell Analysis and Modeling (primary)
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