University of Connecticut

Events Calendar

CCAM Seminar Series - Kshitiz

Thursday, March 8, 2018
4:00pm – 5:00pm

UConn Health
CCAM Conference Room, R1673

CCAM Seminar Series Guest Speaker: Kshitiz, Ph.D., Assistant Professor, Department of Biomedical Engineering, UConn Title: The Stag Hunt Game in Cancer: How Cells Cooperate Within Cancer Populations to Divide in Hypoxia Abstract: Cancer populations, even isogenic ones, undergo role specification during stromal invasion. A typical invading fork of a tumor is led by a migratory leader cells, followed by a rapidly dividing mass of cells. Most tumors exist in hypoxic environments, but paradoxically continue to proliferate, and exhibit metastatic behavior. How do individual cancer cells cooperate to facilitate the emergence of a collective phenotype that facilitates a desired outcome in stress conditions like hypoxia? The first suspect is intercellular communication, but it is not understood how stratification of roles might emerge, particularly when such cooperation would require a subset of cells to make sacrifices. In this talk, we will show how hypoxic cancer cells can undergo quorum sensing to facilitate the emergence of phenotypic heterogeneity within the population.

Contact:

Tiffany x6103

Center for Cell Analysis and Modeling (primary)

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