University of Connecticut

Events Calendar

Neuroscience Seminar Series - Fuchs

Tuesday, January 16, 2018
4:00pm – 5:00pm

UConn Health
Low Learning Center

Sponsored by the Kim Family Fund

Paul Albert Fuchs, Ph.D. John E. Bordley Professor and Vice-director Otolaryngology-Head and Neck Surgery Director, the Center for Hearing and Balance The Johns Hopkins University School of Medicine Baltimore, Maryland

“Functional Diversity Among Cochlear Afferents”

Two classes of primary afferent neurons innervate the mammalian cochlea. The great majority (95%) are larger diameter, myelinated type I spiral ganglion neurons (SGNs) that encode sound. A group of 10-30 type I SGNs are postsynaptic to each inner hair cell (IHC). These share frequency tuning, but differ in rates of spontaneous activity, acoustic threshold and dynamic range. Ongoing studies implicate transmitter release from their respective presynaptic active zones (ribbons) as the source of these functional differences. Still greater functional diversity arises in comparison with type II SGNs. These have thinner, unmyelinated dendrites that project to contact many outer hair cells (OHCs). However, type II afferents are only weakly depolarized by OHC transmitter release and are insensitive to sound. Instead, ATP released during tissue damage excites type II afferents who thereby could signal acoustic trauma - noxacusis.

Host: Dr. Douglas Oliver, doliver@uchc.edu

Contact:

Jody Gridley, gridley@uchc.edu, 860-679-8787

Neuroscience Department at UConn Health (primary), Physiology & Neurobiology, School of Medicine, UConn Health Master Calendar

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