University of Connecticut

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CCAM Seminar Series - Mayu Inaba

Thursday, February 21, 2019
12:00pm – 1:00pm

UConn Health
CGSB, CCAM Conference Room, R1673, 400 Farmington Ave

CCAM Seminar Series Speaker: Mayu Inaba, Assistant Professor Department of Cell Biology, UConn Health Title: "Niche cells restrict self-renewal signaling via receptor-ligand degradation" Abstract: Stem cell niches are believed to play dual, and contrasting roles, maintaining the stem cell population yet limiting stem cell proliferation. How this is achieved, through the short-range signalling that occurs between niche cells and stem cells, remains poorly understood. In our previous paper (Inaba et al, 2015 Nature), we demonstrated that niche/stem cell interactions in the Drosophila testes utilize a specialized cellular protrusion, the microtubule-based nanotube (MT-nanotube). MT-nanotube ensures activation of the Dpp-Tkv signaling only in stem cells. In this study, by investigating the fate of niche ligand/receptor after interaction on the surface of MT-nanotubes, we discovered that not only MT-nanotubes function as a platform of ligand-receptor interaction in a manner that excludes differentiating cells, but also contribute to downregulation of ligand and receptor via sending these into niche lysosomes for degradation, such that excess ligand and receptor are not available to non-stem cells. We believe these results represent a significant advance in stem cell biology and cell signalling, illustrating multilayered functions of MT-nanotubes to ensure the appropriate level of signaling.

Contact:

Tiffany x6103

Center for Cell Analysis and Modeling (primary), School of Medicine

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