University of Connecticut

Events Calendar

CCAM Seminar Series - Haugh

Thursday, November 19, 2015
4:00pm – 5:00pm

Storrs Campus
CCAM Conference Room, R1673, 400 Farmington Ave

CCAM Seminar Series Speaker: Jason Haugh, Professor, Chemical & Biomedical Engineering, North Carolina State University Host: Leslie Loew Title: "Directed migration of mesenchymal cells: by compass or by feel?"

Abstract: Cell migration directed by spatial cues, or taxis, is a primary mechanism for orchestrating concerted and collective cell movements during development, wound repair, and immune responses. Compared with the classic example of amoeboid chemotaxis, in which fast-moving cells such as neutrophils are directed by gradients of soluble factors, directed migration of slow-moving mesenchymal cells such as fibroblasts is poorly understood. Mesenchymal cells possess a distinctive organization of the actin cytoskeleton and associated adhesion complexes as its primary mechanical system, generating the asymmetric forces required for locomotion without strong polarization. The emerging hypothesis is that the molecular underpinnings of mesenchymal taxis involve distinct signaling pathways and diverse requirements for regulation.

We have sought answers to the following questions in the context of mesenchymal cell migration: 1) Locally, how are new protrusions (lamellipodia) initiated and oriented, and how are they stabilized? 2) Globally, how do the dynamics of protrusion govern directional persistence or reorientation of overall cell migration? 3) What signaling and cytoskeletal mechanisms are required for mesenchymal chemotaxis, and are those determinants universal for other forms of directed migration?

Contact:

Tiffany Gough, tgough@uchc.edu

Center for Cell Analysis and Modeling (primary)

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